Atovaquone in Veterinary Medicine: Indications, Contraindications, and Management in Dogs and Cats Introduction Atovaquone is an antiprotozoal and antimicrobial agent primarily used in human medicine for treating Pneumocystis jirovecii pneumonia (PJP), malaria, and certain protozoal infections . In veterinary medicine, it has gained attention for treating Babesiosis, Cytauxzoonosis, and Toxoplasmosis in dogs and cats. The drug is often combined with azithromycin for enhanced efficacy. This guide explores the indications, contraindications, pharmacology, dosage, administration, side effects, and management of Atovaquone in dogs and cats. Pharmacology of Atovaquone Atovaquone is a hydroxynaphthoquinone derivative that acts by inhibiting mitochondrial electron transport, thereby disrupting protozoal ATP synthesis. It has a broad spectrum against Apicomplexan parasites such as Babesia , Cytauxzoon , and Toxoplasma gondii . Due to its lipophilic nature, Atovaquone is best a...
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